Redox tuning of two biological copper centers through non-covalent interactions: same trend but different magnitude.

نویسندگان

  • Siu Yee New
  • Nicholas M Marshall
  • T S Andy Hor
  • Feng Xue
  • Yi Lu
چکیده

The same non-covalent interactions previously found to affect the redox potential (E(m)) of the mononuclear T1 Cu protein azurin (Az) are shown to also fine-tune the E(m) of the dinuclear Cu(A) center in the same Az protein scaffold. The effects of these mutations are in the same direction but with smaller magnitude in the Cu(A) site, due to dissipation of the effects by the dinuclear Cu(A) center.

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عنوان ژورنال:
  • Chemical communications

دوره 48 35  شماره 

صفحات  -

تاریخ انتشار 2012